Article
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature - 11 Nov 1993
Watling D, Guschin D, Müller M, Silvennoinen O, Witthuhn B A, Quelle F W, Rogers N C, Schindler C, Stark G R, Ihle J N
Abstract excerpt
Interferons (IFNs) alpha/beta (type I) and gamma (type II) bind to distinct cell surface receptors, inducing transcription of overlapping sets of genes by intracellular pathways that have recently attracted much attention. Previous studies using cell lines selected for their inability to respond to IFN-alpha (ref. 4) have shown that the protein kinase Tyk2 plays a central role in the IFN alpha/beta response. Here...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.