Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

doi:10.1038/366166a0

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Article

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

Nature - 11 Nov 1993

Watling D, Guschin D, Müller M, Silvennoinen O, Witthuhn B A, Quelle F W, Rogers N C, Schindler C, Stark G R, Ihle J N

Abstract excerpt

Interferons (IFNs) alpha/beta (type I) and gamma (type II) bind to distinct cell surface receptors, inducing transcription of overlapping sets of genes by intracellular pathways that have recently attracted much attention. Previous studies using cell lines selected for their inability to respond...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
CD2 Antigens
Cell Line
DNA-Binding Proteins
Enzyme Activation
Flow Cytometry
Genetic Complementation Test
Humans
Interferon-Stimulated Gene Factor 3
Interferon-Stimulated Gene Factor 3, gamma Subunit
Interferon-alpha
Interferon-beta

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-gamma

Janus Kinase 2

L Cells

Mice

Mutation

Source

Open in PubMed

Identifiers

PMID: 7901766
DOI: 10.1038/366166a0

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7901766-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.