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Article

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions

1 Mar 2025

Abstract excerpt

Abstract Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin 12 family responses. Here we relate the transcriptome changes to phenotypical changes observed in TYK2-deficient ( Tyk2 −/− ) and TYK2 kinase-inactive ( Tyk2 K923E ) mice in naïve splenic immune...

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Identifiers

PMID: 40025196
DOI: 10.1007/s00018-025-05625-9

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