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Article

Differences in Activity between α and β Type I Interferons Explored by Mutational Analysis

1 Apr 1998

Abstract excerpt

Type I interferon (IFN) subtypes alpha and beta share a common multicomponent, cell surface receptor and elicit a similar range of biological responses, including antiviral, antiproliferative, and immunomodulatory activities. However, alpha and beta IFNs exhibit key differences in several biological properties. For example, IFN-beta, but not IFN-alpha, induces the association of tyrosine-phosphorylated receptor...

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PMID: 9525899
DOI: 10.1074/jbc.273.14.8003

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