Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2008

Zhao Wenli, Lee Carolyn, Piganis Rebecca, Plumlee Courtney, de Weerd Nicole, Hertzog Paul J, Schindler Christian

Abstract excerpt

Mammalian type I IFNs (IFN-Is) mediate their potent biological activities through an evolutionarily conserved IFN-alpha receptor (IFNAR), consisting of IFNAR1 and IFNAR2. These two chains direct the rapid activation of two founding members of the STAT family of transcription factors, STAT1 and STAT2. To understand how IFN-Is direct the recruitment and activation of STATs, a series of mutant murine IFNAR1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Macrophages

Share to Mice, Mutant Strains

Share to Receptor, Interferon alpha-beta

Share to STAT1 Transcription Factor

Share to Tyrosine

Source

Identifiers

PMID: 18390731
DOI: 10.4049/jimmunol.180.8.5483

Genes

IFNAR2
IFNAR1
STAT1
STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs.PMID 18390731Read ↗

Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway.Semantic proximity Read ↗

Signaling through a mutant IFN-gamma receptor.Semantic proximity Read ↗

Shared receptor components but distinct complexes for alpha and beta interferons.Semantic proximity Read ↗

The Role of Structure in the Biology of Interferon SignalingSemantic proximity Read ↗

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responsesSemantic proximity Read ↗

Regulating IRFs in IFN Driven DiseaseSemantic proximity Read ↗

STAT3 Negatively Regulates Type I IFN-Mediated Antiviral ResponseSemantic proximity Read ↗

Beyond Good and Evil: Molecular Mechanisms of Type I and III IFN FunctionsSemantic proximity Read ↗

Human Disease Phenotypes Associated with Loss and Gain of Function Mutations in STAT2: Viral Susceptibility and Type I Interferonopathy.Semantic proximity Read ↗

Exposing the Two Contrasting Faces of STAT2 in InflammationSemantic proximity Read ↗

Loss of STAT2 may be dangerous in a world filled with viruses.Semantic proximity Read ↗

Responses to Cytokines and Interferons that Depend upon JAKs and STATs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.