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Article

Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta.

European journal of biochemistry - 15 Jul 1994

Barbieri G, Velazquez L, Scrobogna M, Fellous M, Pellegrini S

Abstract excerpt

We previously demonstrated that the gene tyk2 rescues the phenotype of a human mutant cell line unresponsive to alpha (IFN) and partially responsive to IFN-beta. Here, we describe functional complementation of the mutant cells with the corresponding cDNA. To characterize the putative non-receptor protein tyrosine kinase encoded by the gene tyk2 and begin to understand its functioning, we have raised polyclonal...

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Identifiers

PMID: 8055912
DOI: 10.1111/j.1432-1033.1994.tb19010.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta.PMID 8055912Read ↗

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TYK2 kinase activity is required for functional type I interferon responses in vivo.Semantic proximity Read ↗

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Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditionsSemantic proximity Read ↗

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The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.Semantic proximity Read ↗

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