Article
Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta.
European journal of biochemistry - 15 Jul 1994
Barbieri G, Velazquez L, Scrobogna M, Fellous M, Pellegrini S
Abstract excerpt
We previously demonstrated that the gene tyk2 rescues the phenotype of a human mutant cell line unresponsive to alpha (IFN) and partially responsive to IFN-beta. Here, we describe functional complementation of the mutant cells with the corresponding cDNA. To characterize the putative non-receptor...
Topics
- Cell Membrane
- Cells, Cultured
- Cytosol
- DNA, Complementary
- Enzyme Activation
- Gene Expression Regulation, Enzymologic
- HeLa Cells
- Humans
- Immunoblotting
- Interferon Type I
- Interferon-beta
- Interferon-gamma
- Molecular Weight
- Mutation
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Proteins