Shared receptor components but distinct complexes for alpha and beta interferons.

doi:10.1006/jmbi.1998.2026

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Article

Shared receptor components but distinct complexes for alpha and beta interferons.

Journal of molecular biology - 25 Sept 1998

Lewerenz M, Mogensen K E, Uzé G

Abstract excerpt

The type I interferon family includes 13 alpha, one omega and one beta subtypes recognized by a complex containing the receptor subunits ifnar1 and ifnar2 and their associated Janus tyrosine kinases, Tyk2 and Jak1. To investigate the reported differences in the way that alpha and beta interferons...

Topics

Amino Acid Sequence
Amino Acid Substitution
Binding Sites
Cell Line
Humans
Interferon Type I
Interferon-beta
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Receptors, Interferon
Recombinant Proteins
Sequence Alignment
Signal Transduction
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 9737924
DOI: 10.1006/jmbi.1998.2026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9737924-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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