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Article

Shared receptor components but distinct complexes for alpha and beta interferons.

Journal of molecular biology - 25 Sept 1998

Lewerenz M, Mogensen K E, Uzé G

Abstract excerpt

The type I interferon family includes 13 alpha, one omega and one beta subtypes recognized by a complex containing the receptor subunits ifnar1 and ifnar2 and their associated Janus tyrosine kinases, Tyk2 and Jak1. To investigate the reported differences in the way that alpha and beta interferons signal through the receptor, we introduced alanine-substitutions in the ifnar2 extracellular domain, and expressed the...

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Identifiers

PMID: 9737924
DOI: 10.1006/jmbi.1998.2026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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