Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered translesion synthesis in E. coli Pol V mutants selected for increased recombination inhibition.

DNA repair - 9 Dec 2003

Sommer Suzanne, Becherel Olivier J, Coste Geneviève, Bailone Adriana, Fuchs Robert P P

Abstract excerpt

Replication of damaged DNA, also termed as translesion synthesis (TLS), involves specialized DNA polymerases that bypass DNA lesions. In Escherichia coli, although TLS can involve one or a combination of DNA polymerases depending on the nature of the lesion, it generally requires the Pol V DNA polymerase (formed by two SOS proteins, UmuD' and UmuC) and the RecA protein. In addition to being an essential component...

Topics

DNA
DNA Damage
DNA Replication
DNA-Directed DNA Polymerase
Escherichia coli
Escherichia coli Proteins
Inhibition, Psychological
Mutation
Plasmids
Rec A Recombinases
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sulfolobus

Source

Identifiers

PMID: 14642565
DOI: 10.1016/j.dnarep.2003.08.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered translesion synthesis in E. coli Pol V mutants selected for increased recombination inhibition.PMID 14642565Read ↗

Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors.Semantic proximity Read ↗

Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis.Semantic proximity Read ↗

A defect in homologous recombination leads to increased translesion synthesis in E. coli.Semantic proximity Read ↗

Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.Semantic proximity Read ↗

Characterization of Escherichia coli UmuC active-site loops identifies variants that confer UV hypersensitivity.Semantic proximity Read ↗

Genetic dissection of DNA damage tolerance in Bacillus subtilis: RecA and recombination functions regulate translesion synthesis.Semantic proximity Read ↗

The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis.Semantic proximity Read ↗

Mutations affecting the ability of the Escherichia coli UmuD' protein to participate in SOS mutagenesis.Semantic proximity Read ↗

Genetic and biochemical characterization of a novel umuD mutation: insights into a mechanism for UmuD self-cleavage.Semantic proximity Read ↗

Novel Escherichia coli umuD' mutants: structure-function insights into SOS mutagenesis.Semantic proximity Read ↗

Roles of E. coli double-strand-break-repair proteins in stress-induced mutation.Semantic proximity Read ↗

DNA polymerase V and RecA protein, a minimal mutasome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.