Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered translesion synthesis in E. coli Pol V mutants selected for increased recombination inhibition.

DNA repair - 9 Dec 2003

Sommer Suzanne, Becherel Olivier J, Coste Geneviève, Bailone Adriana, Fuchs Robert P P

Abstract excerpt

Replication of damaged DNA, also termed as translesion synthesis (TLS), involves specialized DNA polymerases that bypass DNA lesions. In Escherichia coli, although TLS can involve one or a combination of DNA polymerases depending on the nature of the lesion, it generally requires the Pol V DNA polymerase (formed by two SOS proteins, UmuD' and UmuC) and the RecA protein. In addition to being an essential component...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Escherichia coli Proteins

Share to Inhibition, Psychological

Share to Rec A Recombinases

Share to Recombination, Genetic

Share to Sulfolobus

Source

Identifiers

PMID: 14642565
DOI: 10.1016/j.dnarep.2003.08.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered translesion synthesis in E. coli Pol V mutants selected for increased recombination inhibition.PMID 14642565Read ↗

Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors.Semantic proximity Read ↗

Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis.Semantic proximity Read ↗

A defect in homologous recombination leads to increased translesion synthesis in E. coli.Semantic proximity Read ↗

Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.Semantic proximity Read ↗

Characterization of Escherichia coli UmuC active-site loops identifies variants that confer UV hypersensitivity.Semantic proximity Read ↗

Genetic dissection of DNA damage tolerance in Bacillus subtilis: RecA and recombination functions regulate translesion synthesis.Semantic proximity Read ↗

The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis.Semantic proximity Read ↗

Mutations affecting the ability of the Escherichia coli UmuD' protein to participate in SOS mutagenesis.Semantic proximity Read ↗

Genetic and biochemical characterization of a novel umuD mutation: insights into a mechanism for UmuD self-cleavage.Semantic proximity Read ↗

Novel Escherichia coli umuD' mutants: structure-function insights into SOS mutagenesis.Semantic proximity Read ↗

Roles of E. coli double-strand-break-repair proteins in stress-induced mutation.Semantic proximity Read ↗

DNA polymerase V and RecA protein, a minimal mutasome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.