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Article

Characterization of Escherichia coli UmuC active-site loops identifies variants that confer UV hypersensitivity.

Journal of bacteriology - 1 Oct 2011

Hawver Lisa A, Gillooly Caitlin A, Beuning Penny J

Abstract excerpt

DNA is constantly exposed to chemical and environmental mutagens, causing lesions that can stall replication. In order to deal with DNA damage and other stresses, Escherichia coli utilizes the SOS response, which regulates the expression of at least 57 genes, including umuDC. The gene products of umuDC, UmuC and the cleaved form of UmuD, UmuD', form the specialized E. coli Y-family DNA polymerase UmuD'2C, or...

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Identifiers

PMID: 21784925
DOI: 10.1128/JB.05301-11
PMCID: PMC3187380

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of Escherichia coli UmuC active-site loops identifies variants that confer UV hypersensitivity.PMID 21784925Read ↗

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