Article
Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors.
Methods in enzymology - 1 Jan 2006
Beuning Penny J, Simon Sharotka M, Godoy Veronica G, Jarosz Daniel F, Walker Graham C
Abstract excerpt
Members of the Y family of DNA polymerases are specialized to replicate lesion-containing DNA. However, they lack 3'-5' exonuclease activity and have reduced fidelity compared to replicative polymerases when copying undamaged templates, and thus are potentially mutagenic. Y family polymerases must be tightly regulated to prevent aberrant mutations on undamaged DNA while permitting replication only under...
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