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Article

Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power.

Human heredity - 1 Jan 2003

Chapman Juliet M, Cooper Jason D, Todd John A, Clayton David G

Abstract excerpt

In the 'indirect' method of detecting genetic associations between a trait and a DNA variant, we type several markers in a gene or chromosome region of linkage disequilibrium. If there is association between markers and the trait, we presume the existence of one or more causal polymorphisms in the region. In order to obtain a sufficiently dense set of markers it will almost always be necessary to use single...

Topics

Data Interpretation, Statistical
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Multivariate Analysis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 14614235
DOI: 10.1159/000073729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14614235-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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