Article
Tag SNP selection for association studies.
Genetic epidemiology - 1 Dec 2004
Stram Daniel O
Abstract excerpt
This report describes current methods for selection of informative single nucleotide polymorphisms (SNPs) using data from a dense network of SNPs that have been genotyped in a relatively small panel of subjects. We discuss the following issues: (1) Optimal selection of SNPs based upon maximizing either the predictability of unmeasured SNPs or the predictability of SNP haplotypes as selection criteria. (2) The...
Topics
- Chromosome Mapping
- Genetic Markers
- Genetic Predisposition to Disease
- Genome, Human
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide
