Article
Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations.
Genetics - 1 Oct 2004
Nielsen Dahlia M, Ehm Margaret G, Zaykin Dmitri V, Weir Bruce S
Abstract excerpt
There has been much recent interest in describing the patterns of linkage disequilibrium (LD) along a chromosome. Most empirical studies that have examined this issue have concentrated on LD between collections of pairs of markers and have not considered the joint effect of a group of markers beyond these pairwise connections. Here, we examine many different patterns of LD defined by both pairwise and joint...
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