Multi-SNP haplotype analysis methods for association analysis.

doi:10.1007/978-1-61779-555-8_23

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Article

Multi-SNP haplotype analysis methods for association analysis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Stram Daniel O, Seshan Venkatraman E

Abstract excerpt

This chapter reviews the rationale for the use of haplotypes in association-based testing, discusses statistical issues related to haplotype uncertainty that complicate the analysis, then gives practical guidance for testing haplotype-based associations with phenotype or outcome trait, first of c...

Topics

Algorithms
Genetic Association Studies
Genetics, Population
Haplotypes
Humans
Likelihood Functions
Pedigree
Polymorphism, Single Nucleotide

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