Multi-SNP haplotype analysis methods for association analysis.

Abstract excerpt

This chapter reviews the rationale for the use of haplotypes in association-based testing, discusses statistical issues related to haplotype uncertainty that complicate the analysis, then gives practical guidance for testing haplotype-based associations with phenotype or outcome trait, first of candidate gene regions and then for the genome as a whole. Haplotypes are interesting for two reasons: First, they may...

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