Article
The haplotype linkage disequilibrium test for genome-wide screens: its power and study design.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2000
Xiong M, Akey J, Jin L
Abstract excerpt
The focus of human genetics continues to shift toward the dissection of complex phenotypes. Integral to these endeavors is the development of powerful analytical tools. To this end, we propose a novel method designated the haplotype linkage disequibrium (LD) test for identifying diseases genes. The basic structure of the haplotype test statistic is a chi-square in which haplotypes, as opposed to individual marker...
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