Article
Analysis of single-locus tests to detect gene/disease associations.
Genetic epidemiology - 1 Apr 2005
Roeder Kathryn, Bacanu Silviu-Alin, Sonpar Vibhor, Zhang Xiaohua, Devlin B
Abstract excerpt
A goal of association analysis is to determine whether variation in a particular candidate region or gene is associated with liability to complex disease. To evaluate such candidates, ubiquitous Single Nucleotide Polymorphisms (SNPs) are useful. It is critical, however, to select a set of SNPs that are in substantial linkage disequilibrium (LD) with all other polymorphisms in the region. Whether there is an ideal...
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