Article
Power and sample size for testing associations of haplotypes with complex traits.
Annals of human genetics - 1 Jan 2006
Schaid Daniel J
Abstract excerpt
Evaluation of the association of haplotypes with either quantitative traits or disease status is common practice, and under some situations provides greater power than the evaluation of individual marker loci. The focus on haplotype analyses will increase as more single nucleotide polymorphisms (SNPs) are discovered, either because of interest in candidate gene regions, or because of interest in genome-wide...
Topics
- Computer Simulation
- Genetic Linkage
- Genetics, Population
- Genomics
- Haplotypes
- Models, Genetic
- Polymorphism, Single Nucleotide
- Quantitative Trait, Heritable
- Research Design
- Sample Size