Article
Multi-SNP Haplotype Analysis Methods for Association Analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Stram Daniel O
Abstract excerpt
Haplotype analysis forms the basis of much of genetic association analysis using both related and unrelated individuals (we concentrate on unrelated). For example, haplotype analysis indirectly underlies the SNP imputation methods that are used for testing trait associations with known but unmeasured variants and for performing collaborative post-GWAS meta-analysis. This chapter is focused on the direct use of...
Topics
- Case-Control Studies
- Genome-Wide Association Study
- Genotyping Techniques
- Haplotypes
- Humans
- Likelihood Functions
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide
- Software
- Uncertainty