Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of family structure on linkage tests using allelic association.

American journal of human genetics - 1 Sept 1998

Whittaker J C, Lewis C M

Abstract excerpt

We considered the problem of testing a marker for linkage with a disease, using tests based on the transmission-disequilibrium test (TDT). The power of such tests was investigated for a number of possible family types, for which the families were classified by the disease status of family individuals. We show that parental disease status greatly affects the power, with families containing a single affected parent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterozygote
Share to Alleles
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Diseases, Inborn

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Models, Statistical

Source

Open in PubMed Open full text

Identifiers

PMID: 9718338
DOI: 10.1086/302008
PMCID: PMC1377396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of family structure on linkage tests using allelic association.PMID 9718338Read ↗

Single-marker family-based association analysis conditional on parental information.Semantic proximity Read ↗

Single Marker Family-Based Association Analysis Conditional on Parental Information.Semantic proximity Read ↗

An evaluation of power and type I error of single-nucleotide polymorphism transmission/disequilibrium-based statistical methods under different family structures, missing parental data, and population stratification.Semantic proximity Read ↗

Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power.Semantic proximity Read ↗

Disease associations and family-based tests.Semantic proximity Read ↗

Disease associations and family-based tests.Semantic proximity Read ↗

Combining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markers.Semantic proximity Read ↗

Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations.Semantic proximity Read ↗

The affected-pedigree-member method: power to detect linkage.Semantic proximity Read ↗

Properties of the transmission-disequilibrium test in the presence of inbreeding.Semantic proximity Read ↗

Power comparisons between the TDT and two likelihood-based methods.Semantic proximity Read ↗

The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.