The effect of family structure on linkage tests using allelic association.

doi:10.1086/302008

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Article

The effect of family structure on linkage tests using allelic association.

American journal of human genetics - 1 Sept 1998

Whittaker J C, Lewis C M

Abstract excerpt

We considered the problem of testing a marker for linkage with a disease, using tests based on the transmission-disequilibrium test (TDT). The power of such tests was investigated for a number of possible family types, for which the families were classified by the disease status of family individ...

Topics

Adult
Alleles
Child
Female
Gene Frequency
Genetic Diseases, Inborn
Heterozygote
Humans
Linkage Disequilibrium
Male
Models, Genetic
Models, Statistical
Nuclear Family
Parents
Paternity

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