Article
Evaluating associations of haplotypes with traits.
Genetic epidemiology - 1 Dec 2004
Schaid Daniel J
Abstract excerpt
Haplotypes have played a major role in the study of highly-penetrant single-gene disorders, and recent evidence that the human genome has hot-spots and cold-spots for recombination have suggested that haplotype-based methods may play a key role in the study of common complex traits. This report reviews the motivation of using haplotypes for the study of the genetic basis of human traits, ranging from biologic...
Topics
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genetics, Population
- Genome, Human
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Models, Statistical
- Phenotype
- Polymorphism, Single Nucleotide