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Article

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

Cell reports - 7 Mar 2017

Ondracek Caitlin R, Frappier Vincent, Ringel Alison E, Wolberger Cynthia, Guarente Leonard

Abstract excerpt

Sirtuin enzymes depend on NAD+ to catalyze protein deacetylation. Therefore, the lowering of NAD+ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD+-depleted environment. These mutant enzymes give rise...

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Share to Acetylation
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Share to NAD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Stability

Share to Saccharomyces cerevisiae

Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 28273448
DOI: 10.1016/j.celrep.2017.02.031
PMCID: PMC5407064

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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