Article
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Science (New York, N.Y.) - 16 Jul 2004
Cohen Haim Y, Miller Christine, Bitterman Kevin J, Wall Nathan R, Hekking Brian, Kessler Benedikt, Howitz Konrad T, Gorospe Myriam, de Cabo Rafael, Sinclair David A
Abstract excerpt
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1...
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