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Article

Structure and stability of cohesin's Smc1-kleisin interaction.

Molecular cell - 24 Sept 2004

Haering Christian H, Schoffnegger Doris, Nishino Tatsuya, Helmhart Wolfgang, Nasmyth Kim, Löwe Jan

Abstract excerpt

A multisubunit complex called cohesin forms a huge ring structure that mediates sister chromatid cohesion, possibly by entrapping sister DNAs following replication. Cohesin's kleisin subunit Scc1 completes the ring, connecting the ABC-like ATPase heads of a V-shaped Smc1/3 heterodimer. Proteolytic cleavage of Scc1 by separase triggers sister chromatid disjunction, presumably by breaking the Scc1 bridge. One half...

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Source

Identifiers

PMID: 15383284
DOI: 10.1016/j.molcel.2004.08.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure and stability of cohesin's Smc1-kleisin interaction.PMID 15383284Read ↗

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