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Article

Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2003

Silha Josef V, Mishra Suresh, Rosen Clifford J, Beamer Wesley G, Turner Russell T, Powell David R, Murphy Liam J

Abstract excerpt

UNLABELLED: IGF-I and their binding proteins are important in bone health. Examination of BMD, osteoblast proliferation, and markers of bone resorption in transgenic mice that constitutively overexpress IGFBP-3 indicates that overexpression of IGFBP-3 increases osteoclast number and bone resorption, impairs osteoblast proliferation, and has a significant negative effect on bone formation. INTRODUCTION: Low serum...

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PMID: 14584894
DOI: 10.1359/jbmr.2003.18.10.1834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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