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Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms.

Endocrinology - 1 May 2006

Silha Josef V, Sheppard Patricia C, Mishra Suresh, Gui Yaoting, Schwartz Jacquie, Dodd Janice G, Murphy Liam J

Abstract excerpt

IGF binding protein (IGFBP)-3 inhibits cell growth and promotes apoptosis by sequestering free IGFs. In addition IGFBP-3 has IGF-independent, proapoptotic, antiproliferative effects on prostate cancer cells in vitro. Expression of the large T-antigen (Tag) under the long probasin promoter (LPB) in LPB-Tag mice results in prostate tumorigenesis. To investigate the IGF-dependent and IGF-independent effects of...

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PMID: 16469805
DOI: 10.1210/en.2005-1270

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