Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice.

doi:10.1016/0955-2235(95)00026-7

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Article

Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice.

Progress in growth factor research - 1 Jan 1995

Murphy L J, Rajkumar K, Molnar P

Abstract excerpt

To provide further insight into the function of the IGFBPs, transgenic (Tg) mice which overexpressed IGFBP-1 and IGFBP-3 were generated. In this report we have compared the phenotypic manifestations observed in these Tg mice. The IGFBP-1 Tg mice were significantly smaller at birth, birth weight a...

Topics

Animals
Body Weight
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Mice
Mice, Transgenic
Organ Size
Phenotype
Reproduction

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