Article
Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2000
Schneider M R, Lahm H, Wu M, Hoeflich A, Wolf E
Abstract excerpt
The insulin-like growth factor-binding proteins (IGFBPs) comprise a family of six related peptides that interact with high affinity with IGFs. IGFBPs compete with IGF receptors for IGF binding, and as a consequence of this competition they can affect cell growth. In addition, IGF-independent regulatory mechanisms of IGFBPs have been described. Despite their common property to interact with IGFs every IGFBP is...
Topics
- Animals
- Female
- Gene Expression
- Glucose
- Growth Disorders
- Homeostasis
- Insulin-Like Growth Factor Binding Proteins
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Phenotype
- Pregnancy
- Reproduction