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Article

Conditional Ablation of the Osteoblast Lineage in Col2.3Δtk Transgenic Mice

1 Dec 2001

Abstract excerpt

Two transgenic mouse lines were generated with a DNA construct bearing a 2.3-kilobase (kb) fragment of the rat alpha1 type I collagen promoter driving a truncated form of the herpes thymidine kinase gene (Col2.3Atk). Expression of the transgene was found in osteoblasts coincident with other genetic markers of early osteoblast differentiation. Mice treated with ganciclovir (GCV) for 16 days displayed extensive...

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Identifiers

PMID: 11760835
DOI: 10.1359/jbmr.2001.16.12.2222

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