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Article

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.

The Journal of clinical investigation - 1 Feb 2004

Sims Natalie A, Jenkins Brendan J, Quinn Julian M W, Nakamura Akira, Glatt Markus, Gillespie Matthew T, Ernst Matthias, Martin T John

Abstract excerpt

The gp130-dependent cytokines, which signal through at least two intracellular pathways, regulate osteoclast and osteoblast formation. To define their roles in regulating bone mass, we analyzed mice in which gp130 signaling via either the signal transducer and activator of transcription (STAT) 1/3 (gp130(DeltaSTAT/DeltaSTAT)) or SHP2/ras/MAPK (gp130(Y757F/Y757F)) pathway was attenuated. In...

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Identifiers

PMID: 14755335
DOI: 10.1172/JCI19872
PMCID: PMC324544

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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