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Article

Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling.

Bone - 1 Sept 2006

Jiang Jin, Lichtler Alexander C, Gronowicz Gloria A, Adams Douglas J, Clark Stephen H, Rosen Clifford J, Kream Barbara E

Abstract excerpt

To determine the effects of locally-expressed insulin-like growth factor (IGF-I) on bone remodeling, a transgene was produced in which murine IGF-I cDNA was cloned downstream of a gene fragment comprising 3.6 kb of 5' upstream regulatory sequence and most of the first intron of the rat Col1a1 gen...

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Identifiers

PMID: 16644298
DOI: 10.1016/j.bone.2006.02.068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16644298-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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