Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice.

Endocrinology - 1 Mar 2005

Silha Josef V, Gui Yaoting, Mishra Suresh, Leckstrom Arnold, Cohen Pinchas, Murphy Liam J

Abstract excerpt

IGF-independent effects of IGF-binding protein-3 (IGFBP-3) have been demonstrated in vitro; however, the physiological significance of these effects in vivo is unclear. We generated two transgenic (Tg) mouse strains that overexpress a human Gly56/Gly80/Gly81-mutant IGFBP-3 cDNA. This mutant has a markedly reduced affinity for the IGFs, but retains the IGF-independent effects. Serum levels of mutant IGFBP-3 were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography
Share to Glycine
Share to Insulin-Like Growth Factor Binding Protein 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Organ Size

Share to Proliferating Cell Nuclear Antigen

Share to Ribonucleases

Share to Tissue Distribution

Source

Identifiers

PMID: 15550509
DOI: 10.1210/en.2004-0905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice.PMID 15550509Read ↗

Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice.Semantic proximity Read ↗

Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice.Semantic proximity Read ↗

Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.Semantic proximity Read ↗

Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5.Semantic proximity Read ↗

Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms.Semantic proximity Read ↗

Gene-targeting and transgenic approaches to IGF and IGF binding protein functionSemantic proximity Read ↗

Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice.Semantic proximity Read ↗

Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction AbnormalitiesSemantic proximity Read ↗

Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation.Semantic proximity Read ↗

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth<sup>1</sup>Semantic proximity Read ↗

Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain.Semantic proximity Read ↗

Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.