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Article

Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice.

Endocrinology - 1 May 2001

Modric T, Silha J V, Shi Z, Gui Y, Suwanichkul A, Durham S K, Powell D R, Murphy L J

Abstract excerpt

In cell culture systems insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) can both enhance and inhibit IGF-I action. To investigate the biological role of IGFBP-3 in vivo, transgenic (Tg) mice that constitutively overexpress the human IGFBP-3 complementary DNA (cDNA) driven by the mouse phosphoglycerate kinase I (PGK) and the cytomegalovirus (CMV) promoters were examined. Serum levels of human IGFBP-3...

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Identifiers

PMID: 11316761
DOI: 10.1210/endo.142.5.8165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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