Article
Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3.
Endocrinology - 1 Aug 1990
Ernst M, Rodan G A
Abstract excerpt
Insulin-like growth factors (IGFs) are bound in the circulation to specific binding proteins (BP). The predominant BP is a GH-dependent glycosylated protein of 42-49 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (BP-3), whereas nonglycosylated GH-independent IGFBPs of 32 kDa an...
Topics
- Amino Acid Sequence
- Animals
- Animals, Newborn
- Binding, Competitive
- Cell Division
- Cell Line
- Cells, Cultured
- DNA Replication
- Gene Expression
- Growth Hormone
- Humans
- Insulin-Like Growth Factor I
- Kinetics
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Osteoblasts
- Procollagen