Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased trabecular bone formation in mice lacking the growth factor midkine.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2010

Neunaber Claudia, Catala-Lehnen Philip, Beil F Timo, Marshall Robert P, Kanbach Vincent, Baranowsky Anke, Lehmann Wolfgang, Streichert Thomas, Ignatius Anita, Muramatsu Takashi, Schinke Thorsten, Amling Michael

Abstract excerpt

Midkine (Mdk) and pleiotrophin (Ptn) comprise a family of heparin-binding growth factors known primarily for their effects on neuronal cells. Since transgenic mice overexpressing Ptn have been reported to display increased bone density, we have previously analyzed Ptn-deficient mice but failed to detect any abnormality of skeletal development and remodeling. Together with the finding that Mdk expression increases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Analysis of Variance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone and Bones

Share to Bone Resorption

Share to Organ Size

Share to Osteoblasts

Share to Osteogenesis

Share to Ovariectomy

Source

Identifiers

PMID: 20200993
DOI: 10.1002/jbmr.75

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased trabecular bone formation in mice lacking the growth factor midkine.PMID 20200993Read ↗

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation.Semantic proximity Read ↗

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.Semantic proximity Read ↗

The protein tyrosine phosphatase Rptpzeta is expressed in differentiated osteoblasts and affects bone formation in mice.Semantic proximity Read ↗

OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.Semantic proximity Read ↗

The ZNF687 mutation of Paget’s disease associated with giant cell tumour causes severe bone remodelling alteration as a result of a deregulated osteoclast transcriptional programSemantic proximity Read ↗

Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization.Semantic proximity Read ↗

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.Semantic proximity Read ↗

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.Semantic proximity Read ↗

Rgnef regulates bone mass through the activation of RhoA and Rac1Semantic proximity Read ↗

Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibitionSemantic proximity Read ↗

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.Semantic proximity Read ↗

Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loadingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.