Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro.

doi:10.1016/j.bone.2004.08.011

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Article

Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro.

Bone - 1 Dec 2004

Durant D, Pereira R M R, Canalis E

Abstract excerpt

Skeletal cells synthesize insulin-like growth factors (IGF) and their binding proteins (IGFBP). The effects of IGFBP-5 on bone cell growth and osteoblastic function are controversial, and transgenic mice overexpressing IGFBP-5 exhibit osteopenia. The mechanisms were not explored, and in this study, we investigated the effects of IGFBP-5 overexpression in MC3T3 cells in vitro. MC3T3 cells were transduced with a...

Topics

3T3 Cells
Animals
Cell Differentiation
Cell Line, Transformed
Gene Expression Regulation
Insulin-Like Growth Factor Binding Protein 5
Mice
Osteoblasts
Phenotype
Protein Binding
RNA, Messenger
Rats
Transduction, Genetic

Source

Open in PubMed

Identifiers

PMID: 15589207
DOI: 10.1016/j.bone.2004.08.011

Provenance

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