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Article

Immune control of tuberculosis by IFN-gamma-inducible LRG-47.

Science (New York, N.Y.) - 24 Oct 2003

MacMicking John D, Taylor Gregory A, McKinney John D

Abstract excerpt

Interferon-gamma (IFN-gamma) provides an essential component of immunity to tuberculosis by activating infected host macrophages to directly inhibit the replication of Mycobacterium tuberculosis (Mtb). IFN-gamma-inducible nitric oxide synthase 2 (NOS2) is considered a principal effector mechanism, although other pathways may also exist. Here, we identify one member of a newly emerging 47-kilodalton (p47)...

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Source

Identifiers

PMID: 14576437
DOI: 10.1126/science.1088063

Genes

NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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