Article
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000
Taylor G A, Collazo C M, Yap G S, Nguyen K, Gregorio T A, Taylor L S, Eagleson B, Secrest L, Southon E A, Reid S W, Tessarollo L, Bray M, McVicar D W, Komschlies K L, Young H A, Biron C A, Sher A, Vande Woude G F
Abstract excerpt
Interferon-gamma (IFN-gamma) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of IFN-gamma-regulated genes that encode 48-kDa GTP-binding proteins that localize to the endoplasmic reticulu...
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