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Article

Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2004

Feng Carl G, Collazo-Custodio Carmen M, Eckhaus Michael, Hieny Sara, Belkaid Yasmine, Elkins Karen, Jankovic Dragana, Taylor Gregory A, Sher Alan

Abstract excerpt

Although IFN-gamma is essential for host control of mycobacterial infection, the mechanisms by which the cytokine restricts pathogen growth are only partially understood. LRG-47 is an IFN-inducible GTP-binding protein previously shown to be required for IFN-gamma-dependent host resistance to acute Listeria monocytogenes and Toxoplasma gondii infections. To examine the role of LRG-47 in control of mycobacterial...

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Source

Identifiers

PMID: 14707092
DOI: 10.4049/jimmunol.172.2.1163

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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