Article

Ly6G <sup>+</sup> Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

2023-10-06

Abstract excerpt

The protective correlates of Mycobacterium tuberculosis ( Mtb ) infection-elicited host immune responses are incompletely understood. Here, we report pro-pathogenic crosstalk involving Ly6G + granulocytes (Ly6G + Gra), IL-17 and COX2. We show that in the lungs of Mtb -infected wildtype mice, either BCG-vaccinated or not, most intracellular bacilli are Ly6G + Gra-resident four weeks post-infection onwards. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e114e3c-0753-5b52-b014-1b71b9967f45
DOI: 10.1101/2023.10.05.561061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ly6G <sup>+</sup> Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesisDOI 10.1101/2023.10.05.561061Read

CCR6 is essential for effective immunity against <i>Mycobacterium tuberculosis</i> infection in miceSemantic proximity Read

Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.Semantic proximity Read

Human IL-6-Producing B Cells Promote the Differentiation of Monocytes Toward an Anti-Inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ Phenotype in Tuberculosis.Semantic proximity Read

Immune control of tuberculosis by IFN-gamma-inducible LRG-47.Semantic proximity Read

Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 PhenotypeSemantic proximity Read

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma ModelSemantic proximity Read

A role for IL-18 in protective immunity against Mycobacterium tuberculosis.Semantic proximity Read

Mice genetically inactivated in interleukin‐17<scp>A</scp> receptor are defective in long‐term control of <i><scp>M</scp>ycobacterium tuberculosis</i> infectionSemantic proximity Read

IL-26 contributes to host defense against intracellular bacteriaSemantic proximity Read

Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis.Semantic proximity Read

T lymphocyte-dependent IL-10 down-regulates a cytokine storm driven by Toxoplasma gondii GRA24Semantic proximity Read

Role of Interleukin 36γ in Host Defense Against TuberculosisSemantic proximity Read