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Article

The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.

PloS one - 31 Dec 2010

Portillo Jose-Andres C, Okenka Genevieve, Reed Erin, Subauste Angela, Van Grol Jennifer, Gentil Katrin, Komatsu Masaaki, Tanaka Keiji, Landreth Gary, Levine Beth, Subauste Carlos S

Abstract excerpt

Autophagy degrades pathogens in vitro. The autophagy gene Atg5 has been reported to be required for IFN-γ-dependent host protection in vivo. However, these protective effects occur independently of autophagosome formation. Thus, the in vivo role of classic autophagy in protection conferred by ada...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21217818
DOI: 10.1371/journal.pone.0014472
PMCID: PMC3013095

Genes

NOS2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21217818-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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