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Article

IRG1 and iNOS act redundantly with other interferon gamma-induced factors to restrict intracellular replication of <i>Legionella pneumophila</i>

2019-08-10

Abstract excerpt

Interferon gamma (IFNγ) restricts the intracellular replication of many pathogens, but how IFNγ confers cell-intrinsic pathogen resistance remains unclear. For example, intracellular replication of the bacterial pathogen Legionella pneumophila in macrophages is potently curtailed by IFNγ, but consistent with prior results, no individual genetic deficiency we tested compromised IFNγ-mediated control. Intriguingly,...

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Literature Corpus work
12b0a6ae-1920-5761-9569-1f1381fda625
DOI
10.1101/731182
Open publication

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