Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005

Sullivan Brandon M, Jobe Ousman, Lazarevic Vanja, Vasquez Kristine, Bronson Roderick, Glimcher Laurie H, Kramnik Igor

Abstract excerpt

A sustained CD4+ Th1-dominated type 1 immune response is required to successfully control Mycobacterium tuberculosis infection. Considerable work has demonstrated that the transcription factor, T-bet, is required for IFN-gamma expression and fundamental to the generation of type 1 immunity in multiple cell types. Mice lacking T-bet are susceptible to virulent M. tuberculosis infection. Susceptibility of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-10

Share to Mycobacterium tuberculosis

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Share to Tuberculosis, Pulmonary

Source

Identifiers

PMID: 16177104
DOI: 10.4049/jimmunol.175.7.4593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.PMID 16177104Read ↗

Noncanonical T cell responses are associated with protection from tuberculosis in mice and humansSemantic proximity Read ↗

Role of Th1/Th17 Balance Regulated by T-bet in a Mouse Model of Mycobacterium avium Complex DiseaseSemantic proximity Read ↗

Diverse roles for T-bet in the effector responses required for resistance to infection.Semantic proximity Read ↗

The immune response in tuberculosis.Semantic proximity Read ↗

Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis.Semantic proximity Read ↗

Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis.Semantic proximity Read ↗

Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological ConsequencesSemantic proximity Read ↗

Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.Semantic proximity Read ↗

Re-appraising the role of T-cell derived interferon gamma in restriction of <i>Mycobacterium tuberculosis</i> in the murine lungSemantic proximity Read ↗

Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responsesSemantic proximity Read ↗

Pathogenicity of Type I Interferons in Mycobacterium tuberculosisSemantic proximity Read ↗

Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.