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Article

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

3 Aug 2006

Abstract excerpt

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and...

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PMID: 16888103
DOI: 10.1126/science.1129577

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