Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

9 Sept 2015

Abstract excerpt

UNLABELLED: A core set of autophagy proteins is required for gamma interferon (IFN-γ)-mediated clearance of Toxoplasma gondii in the mouse because of their control of several downstream effectors, including immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). However, these effectors are absent (i.e., IRGs) from or nonessential (i.e., GBPs) in IFN-γ-activated human cells, raising the question of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Legionella and Acanthamoeba research
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26350966
DOI: 10.1128/mbio.01157-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human CellsPMID 26350966Read ↗

Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite lociSemantic proximity Read ↗

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human CellsSemantic proximity Read ↗

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell deathSemantic proximity Read ↗

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human CellsSemantic proximity Read ↗

Autophagy gene-dependent intracellular immunity triggered by interferon-γSemantic proximity Read ↗

Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against <i>Toxoplasma gondii</i>Semantic proximity Read ↗

Molecular Basis for Interferon-mediated Pathogen Restriction in Human CellsSemantic proximity Read ↗

A Combination of Four Nuclear Targeted Effectors Protects <i>Toxoplasma</i> Against Interferon Gamma Driven Human Host Cell Death During Acute InfectionSemantic proximity Read ↗

IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via AutophagySemantic proximity Read ↗

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondiiSemantic proximity Read ↗

Autophagy gene-dependent intracellular immunity triggered by interferon-γSemantic proximity Read ↗

<i>Toxoplasma</i> -proximal and distal control by GBPs in human macrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.