Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition

15 Oct 2003

Abstract excerpt

The retinoblastoma tumor suppressor protein (RB) is targeted for inactivation in the majority of human tumors, underscoring its critical role in attenuating cellular proliferation. RB inhibits proliferation by repressing the transcription of genes that are essential for cell cycle progression. To repress transcription, RB assembles multiprotein complexes containing chromatin-modifying enzymes, including histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14560017
DOI: 10.1128/mcb.23.21.7719-7731.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle InhibitionPMID 14560017Read ↗

Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin.Semantic proximity Read ↗

HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexesSemantic proximity Read ↗

The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple FrontsSemantic proximity Read ↗

Repression of RNA polymerase III transcription by the retinoblastoma protein.Semantic proximity Read ↗

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer CellsSemantic proximity Read ↗

RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.Semantic proximity Read ↗

RBBP4 modulates gene activity through acetylation and methylation of histone H3 lysine 27Semantic proximity Read ↗

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancerSemantic proximity Read ↗

Histone deacetylase 5 represses the transcription of cyclin D3.Semantic proximity Read ↗

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.Semantic proximity Read ↗

The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphomaSemantic proximity Read ↗

Acetylation control of the retinoblastoma tumour-suppressor protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.