Article

RBBP4 modulates gene activity through acetylation and methylation of histone H3 lysine 27

2021-09-09

Abstract excerpt

RBBP4 is a core subunit of polycomb repressive complex 2 (PRC2) and HDAC1/2-containing complexes, which are responsible for histone H3 lysine 27 (H3K27) methylation and deacetylation respectively. However, the mechanisms by which RBBP4 modulates the functions of these complexes remain largely unknown. We generated viable mouse embryonic stem cell lines with RBBP4 mutations that disturbed methylation and acetylatio...

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Literature Corpus work: a24bdc78-6bf1-5918-9a9a-5dd77834a661
DOI: 10.1101/2021.09.09.459568

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