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Article

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.

The EMBO journal - 3 Jun 2002

Lagger Gerda, O'Carroll Dónal, Rembold Martina, Khier Harald, Tischler Julia, Weitzer Georg, Schuettengruber Bernd, Hauser Christoph, Brunmeir Reinhard, Jenuwein Thomas, Seiser Christian

Abstract excerpt

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously in the repression of genes required for cell proliferation and differentiation. Here we show that targeted disruption of both HDAC1 alleles results in embryonic lethality before E10.5 due to severe proliferation defects and retardation in...

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Source

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Identifiers

PMID: 12032080
DOI: 10.1093/emboj/21.11.2672
PMCID: PMC126040

Genes

HDAC1
HDAC2
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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