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Article

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer

8 Dec 2006

Abstract excerpt

The retinoblastoma tumor suppressor (RB) protein is functionally inactivated in the majority of human cancers and is aberrant in one-third of all breast cancers. RB regulates G(1)/S-phase cell-cycle progression and is a critical mediator of antiproliferative signaling. Here the specific impact of RB deficiency on E2F-regulated gene expression, tumorigenic proliferation, and the response to 2 distinct lines of...

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PMID: 17160137
DOI: 10.1172/jci28803

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