Article
Repression of RNA polymerase III transcription by the retinoblastoma protein.
Nature - 4 Jul 1996
White R J, Trouche D, Martin K, Jackson S P, Kouzarides T
Abstract excerpt
Transcription by RNA polymerase (pol) III is under cell-cycle control, being higher in S and G2 than in G0 and early G1 phases. Many transformed cell types have elevated pol III activity, presumably to sustain sufficient protein synthesis for unrestrained growth. The retinoblastoma tumour-suppres...
Topics
- Adenovirus E1A Proteins
- Animals
- Base Sequence
- Cells, Cultured
- DNA Primers
- Fibroblasts
- Gene Expression Regulation
- Mice
- Molecular Sequence Data
- Mutation
- RNA Polymerase III
- RNA, Viral
- Repressor Proteins
- Retinoblastoma Protein
- Templates, Genetic
- Transcription, Genetic
- Tumor Cells, Cultured
