Article

HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes

2023-10-28

Abstract excerpt

Histone deacetylases (HDACs) are pivotal in transcriptional regulation, and their dysregulation has been associated with various diseases including cancer. One of the critical roles of HDAC-containing complexes is the deacetylation of histone tails, which is canonically linked to transcriptional repression. Previous research has indicated that HDACs are recruited to cell-cycle gene promoters through the RB protein...

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Literature Corpus work: 09d873a1-5463-5c7b-90c5-01dc0269f05f
DOI: 10.1101/2023.10.28.564489

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