Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin.

Abstract excerpt

Cancer cells exhibit a set of unique properties that distinguish them from their normal counterparts. Among these features are increased growth rates, loss of differentiation, escape from cell death pathways, evasion of anti-proliferative signals, a decreased reliance on exogenous growth factors and escape from replicative senescence. Acquisition of these features by malignant cells requires impairment of normal...

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